Antiviral Drugs - From Basic Discovery Through Clinical Trials

A complete, one-stop reference to real-world antiviral drug discovery and development§The field of antiviral drugs continues to evolve at a fast pace in response to new virus discoveries and development of viral resistance to existing therapies. This book provides case histories and arms both basic and industrial pharmaceutical researchers with practical tools to tackle the ongoing challenges of antiviral drug design, discovery, and development.§Written by leading authorities from academia and industry, Antiviral Drugs compiles information previously scattered across the literature into one complete, self-contained volume, unlike any other book on the subject. The authors draw on their own extensive research experience to present numerous case studies illustrating the full drug design process, from bench to clinic, with special emphasis on proven strategies for the development of drugs against all major viral infectious diseases, including HIV, HCV, RSV, influenza, HBV, and CMV.§Readers will find everything they need to analyze, understand, and apply discovery and development principles, including:§Coverage of newly approved antiviral drugs and compounds in clinical development§Emphasis on novel experimental molecules used to combat viral infections§Viral inhibitory mechanistic information§Clear examples for how to bring drugs from laboratory discovery to clinical trials§Effective examples and strategies of lead optimization yielding molecules of clinical value§Practical solutions for issues such as pharmacokinetics, viral resistance, and more§Key and specific references for readers wishing to explore the topics further