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Computational methods are playing an ever increasing role in cell biology. This volume of Methods in Cell Biology focuses on Computational Methods in Cell Biology and consists of two parts: (1) data extraction and analysis to distill models and mechanisms, and (2) developing and simulating models to make predictions and testable hypotheses. §Focuses on Computational Methods in Cell Biology Split into 2 parts - data extraction and analysis to distill models and mechanisms, and developing and simulating models to make predictions and testable hypotheses. Emphasizes the intimate and necessary connection with interpreting experimental data and proposing the next hypothesis and experiment. §