Drug Discovery Stories

The field of drug discovery and development has experienced rapid evolution, with numerous new drugs receiving approval each year. While several books have been published on this subject, there is a pressing need for a new book series that accurately reflects the current advancements in drug discovery. This book aims to not only cater to the drug discovery community but also engage other communities involved in chemical biology, synthetic chemistry, and pharmacology. By showcasing how their work is utilized or has the potential to be utilized in the realm of drug discovery, this series intends to foster interdisciplinary collaboration and knowledge exchange. Considering the dynamic nature of drug discovery and development, where progress is swift and continuous, the authors have planned to release updated editions of the book every few years, ensuring that the content remains up to date with the latest achievements and breakthroughs in the field. Drug Discovery Stories: From Bench to Bedside presents a collection of cases on the development of highly successful pharmaceuticals that have gained worldwide approval. It delves into the realm of drug discovery, exploring the structural biology and biological functions of the sought-after targets. The manuscript covers the identification of promising compounds, their transformation from hits to leads through meticulous optimization, and the elucidation of how key compounds interact with the target (in essence, providing invaluable insights for drug design). Additionally, it covers essential information such as the pivotal biological and PK data of lead compounds, any noteworthy clinical results, and a comprehensive overview of other candidate compounds in various stages of preclinical and clinical development, all aimed at targeting the same desired outcome. Analyzes the drug discovery stories of different blockbuster drugsIncludes the newly approved drugsCovers key aspects related to the drug development of the drugs (detailed).