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Hepatic Fibrosis: Mechanisms and Targets: Mechanisms and Targets is a complete volume of liver extracellular matrix biology, including molecular signaling pathways, cells, and factors that modulate fibrogenesis and fibrosis. It uses an integrated approach toward the molecular and cellular mechanisms involved in the synthesis and degradation of hepatic fibrotic tissue, emphasizing the possible molecular targets to fight fibrosis. This important reference describes in detail and didactically the cellular and molecular events that are conducive to fibrosis, leading to cirrhosis, hepatocellular carcinoma, and death. The provided information allows readers to understanding the molecular mechanisms of hepatic fibrogenesis to accelerate the development of new therapies based on specific targets and the discovery of new markers of liver fibrosis to evaluate patients' outcomes and to monitor the response to treatments. Presents the progression from inflammation to fibrosis with a special focus on the molecular mechanisms involved Didactically explains the participation of cells, cytokines, and factors in profibrogenic pathways Illuminates the causative participation of free radicals in liver fibrogenesis Explains the role of gut dysbiosis in chronic liver diseases leading to fibrosis Provides experimental models to study liver fibrosis and describes the available noninvasive methods to monitor it
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