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This book is the result of a ground-breaking collaboration of approximately 100 individuals and organizations, with diverse perspectives and insights on a central healthcare perspective. The book will help clinical decision support implementers improve medication use in their organizations by providing practical recommendations for successfully implementing CDS focused on these targets. Chapters include detailed guidance on key areas in an effective CDS-medication management program, including optimizing governance structures and management processes, defining outcome improvement opportunities and baselines, and setting up interventions in key clinical information systems.