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This Reprint focuses on studies describing the role of mineral nutrition and status in the maintenance of human health and in the etiology, management, and prevention of common chronic diseases impacting large proportions of the population. Studies published herein focus on the interplay between mineral nutrition and diseases, such as anemia, cancer, diabetes, osteoporosis, cardiovascular disease, and hypertension. The findings from these studies are important in that they can improve guidelines regarding mineral nutrition during the etiology and treatment of disease and enhance our understanding of how changes in mineral bioavailability, metabolism, and physicochemical properties influence disease. This Reprint presents novel findings in the field of mineral nutrition and contributes to our understanding of the role of minerals in human disease.