Contacto
Cómo comprar
Entrega
Guía de compras
Mitochondrial Alterations in Solid Carcinomas
Relationship between Tumorgenesis of Human Kidney Carcinomas and Mitochondrial DNA (mtDNA) Alterations
Inglés
130 b
Hasta 30 días para devoluciones
Clientes que también han comprado
/
Tapa dura
48.59
€
/
Tapa blanda
42.39
€
/
Tapa blanda
21.79
€
Alterations of the respiratory chain and mutations of the mitochondrial DNA (mtDNA) have been extensively investigated in a wide variety of neoplasias. However, no obvious correlation of a certain type of tumor and mtDNA mutations has been reported so far. I compared both, enzymatic measurements of the respiratory chain and mtDNA mutations in renal carcinomas and renal oncocytomas. To enable a high throughput screen of mtDNA variations, I developed a DHPLC-based protocol for a rapid detection of unknown variations of the entire human mtDNA. The benign renal oncocytomas were in clear contrast to the malign renal carcinomas. The oncocytomas showed significantly increased Krebs cycle- and OXPHOS enzyme activities, except a total breakdown of the complex I enzyme activity. The mutation screening revealed frame shift mutations, encoding mitochondrial ND genes in 8 out of 12 oncocytomas. All these somatic frame shift mutations displayed a homoplasmy of 100%. This study shows for the first time a direct correlation of mtDNA mutations in a specific type of cancer, which leads to a total lack of complex I enzyme activity in the respiratory chain.
Sobre el libro
Inglés
Regale este libro hoy
Es fácil
1 Añadir al carrito y elegir Entregar como regalo en el checkout 2 Le enviaremos un vale 3 El libro llegará a la dirección del destinatarioTambién puede interesarle
/
Tapa dura
35.29
€
/
Tapa blanda
17.19
€
/
Tapa blanda
9.89
€
/
Tapa blanda
7.79
€
/
Tapa blanda
22.99
€
/
Tapa dura
215.89
€
¡Hola! Soy Libroamiko, tu asesor de libros.
¿Cómo puedo ayudarte?