Molecular Insights into Proteinopathies

Molecular Insights into Proteinopathies: Increased Scope from Neurodegeneration to other Pathologies of the Brain investigates the molecular events that lead to various diseases. The book is divided into four parts, the first of which delves into protein aggregation across a range of diseases, including Alzheimer’s disease, Parkinson’s disease, schizophrenia, neuropsychiatric disease. It then moves on to discuss signaling pathways and biomarkers of disease, including oxidative stress, mitochondrial decline, and dysregulated molecular pathways. The third part explores small molecules as modulators of key processes in the pathogenesis of proteinopathies, including antioxidants, polyphenol compounds, metal chelators, and repurposed drugs that modulate proteinopathies. The final section considers biophysical methods, molecular dynamics and machine learning approaches in the study of these aspects. This book provides a detailed overview of protein dysfunction and its implications for health and disease, aiding understanding of protein condensates and aggregates, protein misfolding, co-chaperoning and toxicity of pre-amyloid aggregates. By understanding the fundamental properties underlying these, the book paves the way for investigating how proteinopathies could be treated. This book is an ideal reference for researchers working across cell biology, molecular biology, neuroscience and related fields.

• Investigates proteostasis dysfunction across a range of proteinopathies including Alzheimer's disease and Parkinson’s disease
• Considers biophysical techniques, molecular dynamics and machine learning to study molecular mechanisms
• Explores small molecules as modulators of the key processes in proteinopathies
• Provides a basis for further study on potential therapeutic intervention to treat proteinopathies