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This volume covers data describing the role in gingivitis and periodontal disease of free radicals and antioxidants (i.e. oxidative stress). Its goal is to keep the dentist and research scientist up-to-date on translational research into dental applications. Oxidative stress plays a regulatory role in transcription, signal transduction, gene expression and membrane trafficking. There has been a tremendous increase in the research in this area. The editors are internationally recognized scientists who have been instrumental in furthering our understanding of oxidative stress and antioxidant disease processes in periodontal diseases. Chapter authors are experts in the field and have published extensively. Divided into four sub-sections, the chapters covers the gamut of oxidative stress as related to gum and plaque development, the roles of enzymes, the pathogenesis of periodontal diseases, the effect of apoptosis, the role of nutrition in periodontitis, and new theories and therapies in clinical treatment of these disorders.